The purpose of this memo is to provide North Carolina Immunization Program (NCIP) providers with the latest information on the 2025-2026 COVID-19 vaccine. Please take time to carefully review this memo in full. COVID-19 vaccines for VFC eligible patients are now available to order through NCIR.
On October 6, 2025, Acting CDC Director and Deputy Secretary of Health and Human Services Jim O’Neill approved the Advisory Committee on Immunization Practices (ACIP) COVID-19 vaccine recommendations. The CDC will update its immunization schedules to individual-based (shared clinical) decision-making for COVID-19 vaccination for 6 months and older, after consultation with a healthcare provider.
COVID-19 Vaccines Available for 2025-2026 Season
| NDC | Manufacturer | Brand | Presentation | Age Group Covered | Storage Guidelines |
|---|---|---|---|---|---|
| 80777-0113-80 | Moderna | Spikevax® 2025-2026 Formula (6m-11y) | 0.25mL single dose prefilled syringe, 10 pack | VFC children 6 mos. to 11 years of age | Frozen (-50°C to -15°C) or 60 days refrigerated (2°C to 8°C) |
| 80777-0112-96 | Moderna | Spikevax® 2025-2026 Formula (12y+) | 0.5mL single dose prefilled syringe, 10 pack | VFC children 12-18 years of age | Frozen (-50°C to -15°C) or 60 days refrigerated (2°C to 8°C) |
| 80631-0207-10 | Sanofi | NuvaxovidTM 2025-2026 Formula (12y+) | 0.5mL single dose prefilled syringe, 10 pack | VFC children 12-18 years of age | Refrigerated (2°C to 8°C) |
| 00069-2501-10 | Pfizer | Comirnaty® 2025-2026 Formula (5-11y) | 0.3mL single dose vial, 10 pack | VFC children 5-11 years of age | ULC (-90°C to -60°C) or 10 weeks refrigerated (2°C to 8°C) |
| 0069-2528-10 | Pfizer | Comirnaty® 2025-2026 Formula (12y+) | 0.3mL single dose prefilled syringe, 10 pack | VFC children 12-18 years of age | Refrigerated (2°C to 8°C) |
Key Points
- Since the approval of the 2025-2026 COVID-19 vaccines, any remaining 2024-2025 doses on hand are no longer authorized/recommended. They must be immediately removed from storage, recorded in NCIR as wasted, and returned per routine NCIP vaccine wastage guidelines. Providers should choose “Recall” as the wastage reason. Administration of non-authorized products is considered a vaccine administration error and must be reported to VAERS.
- The Centers for Disease Control and Prevention (CDC) Child, Adolescent, and Adult Immunization Schedules with revised COVID-19 vaccine recommendations are expected to be updated on October 7, 2025.
- 2025 VFC provider stock: VFC providers are no longer required to routinely stock COVID-19 vaccines but must refer VFC-eligible children to a safety net provider (e.g., Local Health Department) if needed. LHDs should maintain a minimum VFC stock to support referrals.
- Due to uncertain demand of the COVID-19 vaccine, providers will not be penalized for expired or outdated vaccines.
- Only NCIP providers can order the 2025-2026 COVID-19 vaccines for their VFC eligible populations through NCIR.
- The NCIP is unable to offer 317 VFA 2025-2026 COVID-19 vaccines this season.
Providers are encouraged to review the NCDHHS COVID-19 web page and talk with their patients about protecting them from COVID-19.
How to Contact Us
For assistance, please contact the NCIP Help Desk by phone at 1.877.USE.NCIR (1-877-873-6247) or by email.
Thank you for your ongoing partnership and dedication to improving immunization outcomes in North Carolina.
In Health,
NC Department of Health and Human Services