North Carolina Vaccines for Children (VFC) providers can now order the pentavalent meningococcal (A,B,C,W, and Y) vaccine, PENMENVY™ (NDC 58160-757-15) via NCIR for administration to their VFC-eligible adolescents (ages 10 through 18 years).
About PENMENVY™
PENMENVY™ is licensed as a two-dose series (administered six months apart) to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, B, C, W, and Y in individuals 10 through 25 years of age. The Advisory Committee on Immunization Practices (ACIP) recommends PENMENVY™ be used when both MenACWY and MenB vaccines are indicated at the same visit:
- Routine schedule: healthy individuals aged 16-23 years when shared clinical decision-making favors administration of MenB.
- For individuals at increased risk of meningococcal disease aged 10 years and older who are due for both vaccines.
Reminder: MenB vaccines are not interchangeable. The same vaccine (either BEXSERO by GSK or TRUMENBA® by Pfizer) must be used for all doses in the MenB series, including booster doses. The pentavalent MenABCWY product PENMENVY™ (GSK) contains MenB-4C (BEXSERO) as its MenB component; therefore, PENMENVY™ should only be used in a series with BEXSERO.
Storage and Handling
PENMENVY™ is supplied in cartons containing:
- 10 vials of Lyophilized MenACWY Component (powder)
- 10 prefilled TIP-LOK syringes (Luer Lock syringes) of MenB Component (liquid) packaged without needles
Prepare PENMENVY™ by reconstituting the Lyophilized MenACWY Component with the MenB Component. After reconstitution, administer a single dose (0.5mL) of PENMENVY™ via the intramuscular route.
Prior to reconstitution, PENMENVY™ must be stored refrigerated (2°C to 8°C) in the original package.
More Resources
Please review the following resources with clinical staff:
- CDC Meningococcal Vaccine Recommendations (No MMWR yet; updated guidance expected soon)
- PENMENVY Package Insert (PDF)
- How to Prepare (PDF)
How to contact us:
Questions about the availability of PENMENVY™ should be directed to our NCIP Help Desk at 1-877-873-6247. Clinical questions about PENMENVY™ should be directed to our NCIP on-call nurses at 919-707-5575.
Thank you for your ongoing partnership and dedication to improving immunization outcomes in North Carolina.
In Health,
NC Department of Health and Human Services